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Biobank Borealis briefly in English

Etusivu > Tutkimus ja opetus > Biopankki > Biobank Borealis briefly in English

​What are biobanks?

A biobank is a collection of human samples (e.g. tissue, blood, cells, extracted DNA) that is linked to the sample donor’s health data (with the informed consent of the donors). Samples for clinical studies and diagnostic purposes have been collected throughout the history of medicine, but in the new biobank concept, defined by the Biobank Act, the collected samples can be used for a variety of future research needs, not just for a defined specific research purpose as previously. Furthermore, the new research results are obliged to be returned to the biobank that further enriches its data set.

Biobanks are key resources for unravelling the molecular basis of disease subtypes, identification of new therapeutic targets and biomarkers – all of which lead to personalized healthcare and more effective treatment strategies via translational medical research. Especially the digitalization of biological samples and generation of big data will create great opportunities to develop new forms of treatment, targeted drugs and health services.

Biobank Borealis of Northern Finland

Northern Ostrobothnia Hospital District, the University of Oulu, NordLab and the hospital/healthcare districts of Lapland, Länsi-Pohja, Central Ostrobothnia and Kainuu have established a biobank in Northern Finland. The Borealis Biobank closely collaborates with the Medical Research Center Oulu. The Finnish biobank collaborate via the national BBMRI.fi (Biobanking and Biomolecular Resources Research Infrastructure) network.

 

What types of samples the Borealis biobank includes?

  • The sample archive transferred from Pathology department of the Oulu University Hospital includes 1 800 000 pathology tissue and cell samples beginning from 1978. In addition, the pathology archives of four central hospital starting from early 90s are included in the Biobank Borealis collections.
  •  A rapidly growing collection of blood samples (serum, plasma, DNA) collected from people who have signed a prospective consent to participate in Biobank Borealis.
  • The Finnish Maternity Cohort (FMC) collection contains over 2 million serum samples, collected from mothers living in Finland during their pregnancies. The FMC material was transferred to Biobank Borealis in fall 2017. Based on the FMC sample material, hundreds of scientific articles and doctoral dissertations have been published since 1985.  FMC Publications 

Researchers have the opportunity to collect sample materials for their projects in collaboration with the biobank, e.g. focusing on certain diseases
A preliminary feasibility mapping or study of the research materials can be conducted cost-effectively in the early stages of the research project.

How to obtain samples, services and data from Biobank Borealis?

The biobank can assign samples and related data only for high-quality health sciences research and development. A scientific committee will evaluate all sample and data requests. Contact Biobank Borealis with a preliminary research plan to find out whether biobank Borealis has the material that could be used in your research. Contact via email (BiopankkiBorealis@ppshp.fi ) or call us (+358 40 5049025). If the sample collections of biobank Borealis contain the materials you need, please send the attached

Biobank Request Form (In English) to BiopankkiBorealis@ppshp.fi or by mail directly to the Biobank.

Request for Samples - other account for ethical evaluation

Biobank's Scientific Committee will evaluate the requests in its next meeting, which take place once a month. Specifically, the Scientific Committee evaluates the scientific level, significance and ethicality of the research project. The amount of requested material will be assessed in relation to the number of available samples and defines the criteria for selecting the samples for the research project. Additional inquiries may be submitted to the researcher. Based on the decision of the scientific committee, the manager of the biobank decides on the transfer of the material.

Following a positive decision, a material transfer agreement with the researcher's organization will be signed, and then the data can be transferred.  At the end of the study, the analysed results related to the samples and / or the raw data will be returned to the biobank as stated in the Material transfer agreement. The results of the study must also be published, e.g. in a scientific peer-reviewed journal.

How to apply for Finnish Maternity Cohort -samples

 

Biobank scanner instructions for researchers.docx

Biobank excel sheet for scanner.xlsx

Scientific Committee

The Borealis Biobank Scientific Committee evaluates the scientific level, significance and ethical aspects of the research project. In addition, it will assess the amount of requested material in relation to the number of available samples and defines the criteria for selecting the samples for the research project. Additional inquiries may be submitted to the researcher, e.g. the Scientific Steering Committee may request that the application be supplemented with a statement by a regional ethics committee, as referred to in the Medical Research Act, or other additional statements.

Based on the opinion of the scientific committee, the director of the biobank decides on the transfer of the material.  After a positive decision, a Material Transfer Agreement with the researcher's background organization will be signed, after which the samples and the related data can be transferred. At the end of the study, the analyzed results and/or the raw data will be returned to the biobank as stated in the Material Transfer Agreement. The results of the study must also be published, e.g. in a scientific peer-reviewed journal.

 

Composition of the Scientific Committee

 The Scientific Committee covers a wide range of medical expertise. The committee may also request outside expert evaluations if needed.

Chair

  • Paavo Pääkkö, chief physician, Oulu University Hospital/pathology (vice-chair Tuomo Karttunen, professor, University of Oulu, Research unit of cancer and translational medicine)

Members

  • Minna Mäkiniemi, PhD, research services manager, secretary of regional ethical committee
  • Jukka Moilanen, docent, chief physician, medical genetics, (vice Outi Kuismin, associate chief physician)
  • Minna Männikkö, docent, research director, Northern Finland Birth Cohorts  (vice Juha Auvinen, MD)
  • Petri Lehenkari, professor, specialist in surgery (vice Juha Saarnio, docent, head of section, surgery)
  • Johanna Myllyharju, professor, Faculty of biochemistry and molecular medicine (vice Peppi Karppinen, professor)
  • Tuula Toljamo, docent, clinical director, lung diseases (vice Paavo Uusimaa, clinical director, docent, internal medicine)
  • Jussi Koivunen, docent, specialist in oncology (vice Arja Jukkola-Vuorinen, head of section, docent, oncology)
  • Miia Turpeinen, docent, specialist, pharmacology (vice Jukka Hakkola, professor, pharmacology)
  • Eeva-Riitta Savolainen, docent, head of section, laboratory medicine (vice Sohvi Hörkkö, chief physician, professor, microbiology)

    Presenting official
  • Pia Nyberg, docent, deputy director of biobank

    Secretary
  • Tiina Pekkala, MSc (Health Sci) (vice Pia Nyberg)

 

Meetings of the Scientific Committee (last day to submit the material in parentheses) 2018:

  • 18JAN (04JAN)
  • 15FEB (01FEB)
  • 22MAR (08MAR)
  • 19APR (05APR)
  • 17MAY (03MAY)
  • 14JUN (31MAY)
  • 09AUG (26JUL)
  • 06SEP (23AUG)
  • 04OCT (20SEP)
  • 08NOV (25OCT)
  • 13DEC (29NOV)

 

Biobank Services for Researchers

The  biobank offers the

  • Opportunity to obtain large sets of high-quality sample materials linked to various clinical data, collected and stored in controlled conditions. In addtiution to that, biobank Borealis offers various services related to e.g. researcjh infrastructures. 
  • Collection of biobank consents, samples and related data in collaboration with researchers
  • Provision of infrastructure and tools related to the storage, management and search of samples and data
  • Opportunities for R&D collaboration in data mining and in the utilization of analysis tools. The Oulu region is a particularly attractive place for multidisciplinary research cooperation between medicine, life sciences and ICT.
  • Digitalization of tissue samples.
  • Hardware and related services in Whole Slide Imaging/Digital Pathology
  • Planning and production of tissue microarray (TMA) blocks
  • Processing and analysis of samples
  • Histological processing of tissue samples
  • Isolated DNA

The fees for the services are are based on a price list negotiated on a case-by-case basis.

 

Additional information

BBMRI Finland

Medical Research Center (MRC) Oulu