Etusivu > Palvelut > Lapset ja nuoret > Oulun Craniofaciaalikeskus > Tieteellinen tutkimus- ja kehitystyö

Tieteellinen tutkimus- ja kehitystyö

​Oulun craniofaciaalikirurginen keskus tekee kansainvälistä huippututkimusta, ja keskuksessa on otettu uusimpia kansainvälisesti hyviksi havaittuja tekniikoita esimerkiksi kallon tilavuuden laajentamisessa käyttöön tiettävästi ensimmäisenä Skandinaviassa.

Osaamiskeskuksen leikkaustiimi on viime vuosien aikana julkaissut ja raportoinut havainnoistaan lääketieteellisissä julkaisuissa viime aikoina muiden muassa seuraavista aiheipiireistä:

1: Salokorpi N, Vuollo V, Sinikumpu JJ, Satanin L, Nestal Zibo H, Ylikontiola LP,Pirttiniemi P, Sándor GK, Serlo W. Increases in Cranial Volume with Posterior Cranial Vault Distraction in 31 Consecutive Cases. Neurosurgery. 2017 Apr 5. doi:10.1093/neuros/nyx125. [Epub ahead of print] PubMed PMID: 28383737.

2: Lappalainen OP, Karhula SS, Haapea M, Kauppinen S, Finnilä M, Saarakkala S, Serlo W, Sándor GK. Micro-CT Analysis of Bone Healing in Rabbit Calvarial Critical-Sized Defects with Solid Bioactive Glass, Tricalcium Phosphate Granules or Autogenous Bone. J Oral Maxillofac Res. 2016 Jun 30;7(2):e4. doi:10.5037/jomr.2016.7204. eCollection 2016 Apr-Jun. PubMed PMID: 27489608; PubMed Central PMCID: PMC4970504.

3: Lappalainen OP, Haapea M, Serpi R, Lehtonen S, Ylikontiola L, Korpi J, Serlo W, Sándor GK. Iron-labeled adipose stem cells and neovascularization in rabbitcalvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol.2016 May;121(5):e104-10. doi: 10.1016/j.oooo.2016.01.006. Epub 2016 Jan 14.PubMed PMID: 27017402.

4: Lappalainen OP, Karhula S, Haapea M, Kyllönen L, Haimi S, Miettinen S, Saarakkala S, Korpi J, Ylikontiola LP, Serlo WS, Sándor GK. Bone healing in rabbit calvarial critical-sized defects filled with stem cells and growth factors combined with granular or solid scaffolds. Childs Nerv Syst. 2016 Apr;32(4):681-8. doi: 10.1007/s00381-016-3017-2. Epub 2016 Jan 19. PubMed PMID: 26782995.

5: Posti JP, Piitulainen JM, Hupa L, Fagerlund S, Frantzén J, Aitasalo KM, Vuorinen V, Serlo W, Syrjänen S, Vallittu PK. A glass fiber-reinforced composite - bioactive glass cranioplasty implant: A case study of an early development stage implant removed due to a late infection. J Mech Behav Biomed Mater. 2015 Mar;55:191-200. doi: 10.1016/j.jmbbm.2015.10.030. Epub 2015 Nov 7. PubMed PMID: 26594779.

6: Salokorpi N, Sinikumpu JJ, Iber T, Zibo HN, Areda T, Ylikontiola L, Sándor GK, Serlo W. Frontal cranial modeling using endocranial resorbable plate fixation in 27 consecutive plagiocephaly and trigonocephaly patients. Childs Nerv Syst. 2015  Jul;31(7):1121-8. doi: 10.1007/s00381-015-2657-y. Epub 2015 Feb 26. PubMed PMID: 25715840.

7: Piitulainen JM, Posti JP, Aitasalo KM, Vuorinen V, Vallittu PK, Serlo W. Paediatric cranial defect reconstruction using bioactive fibre-reinforced composite implant: early outcomes. Acta Neurochir (Wien). 2015 Apr;157(4):681-7. doi: 10.1007/s00701-015-2363-2. Epub 2015 Feb 10. PubMed PMID: 25663141.

8: Lappalainen OP, Korpi R, Haapea M, Korpi J, Ylikontiola LP, Kallio-Pulkkinen S, Serlo WS, Lehenkari P, Sándor GK. Healing of rabbit calvarial critical-sized defects using autogenous bone grafts and fibrin glue. Childs Nerv Syst. 2015 Apr;31(4):581-7. doi: 10.1007/s00381-014-2588-z. Epub 2014 Nov 13. PubMed PMID: 25391980.

10: Aarnivala H, Vuollo V, Harila V, Heikkinen T, Pirttiniemi P, Holmström L, Valkama AM. The course of positional cranial deformation from 3 to 12 months of age and associated risk factors: a follow-up with 3D imaging. Eur J Pediatr. 2016 Dec;175(12):1893-1903. Epub 2016 Sep 13. PubMed PMID: 27624627.

11: Vuollo V, Holmström L, Aarnivala H, Harila V, Heikkinen T, Pirttiniemi P,Valkama AM. Analyzing infant head flatness and asymmetry using kernel density estimation of directional surface data from a craniofacial 3D model. Stat Med.2016 Nov 20;35(26):4891-4904. doi: 10.1002/sim.7032. Epub 2016 Jul 6. PubMed PMID: 27383684.

12: Aarnivala H, Vuollo V, Harila V, Heikkinen T, Pirttiniemi P, Valkama AM. Preventing deformational plagiocephaly through parent guidance: a randomized, controlled trial. Eur J Pediatr. 2015 Sep;174(9):1197-208. doi:10.1007/s00431-015-2520-x. Epub 2015 Apr 1. PubMed PMID: 25823758.

13: Aarnivala HE, Valkama AM, Pirttiniemi PM. Cranial shape, size and cervicalmotion in normal newborns. Early Hum Dev. 2014 Aug;90(8):425-30. doi:10.1016/j.earlhumdev.2014.05.007. Epub 2014 Jun 13. PubMed PMID: 24951081. 

14: Salokorpi N, Sándor GK, Sinikumpu JJ, Ylikontiola L, Serlo W. A new technique to facilitate optimal directions for cranial distractor implantation. Childs NervSyst. 2013 Aug;29(8):1359-61. doi: 10.1007/s00381-013-2144-2. Epub 2013 May 12.PubMed PMID: 23666432. 

15: Salokorpi, N., Sándor, G. K., Sinikumpu, J. J., Ylikontiola, L., & Serlo, W. (2013). A new technique to facilitate optimal directions for cranial distractor implantation. Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery.

16: Serlo WS, Ylikontiola LP, Lähdesluoma N, Lappalainen OP, Korpi J, Verkasalo J, Sàndor GK. Posterior cranial vault distraction osteogenesis in craniosynostosis: estimated increases in intracranial volume. Childs Nerv Syst. 2011 Apr;27(4):627-33. Epub 2010 Dec 2.

17: Sándor GK, Ylikontiola LP, Serlo W, Pirttiniemi PM, Carmichael RP. Midfacial distraction osteogenesis. Atlas Oral Maxillofac Surg Clin North Am. 2008, Sep;16(2):249-72. Review. PubMed PMID: 18710695.

18: Sándor GK, McGuire TP, Ylikontiola LP, Serlo WS, Pirttiniemi PM. Management of facial asymmetry. Oral Maxillofac Surg Clin North Am. 2007 Aug;19(3):395-422, vi. Review. PubMed PMID: 18088893.

19: Sándor GK, Ylikontiola LP, Serlo W, Carmichael RP, Nish IA, Daskalogiannakis J. Distraction Osteogenesis of the Midface. Oral Maxillofac Surg Clin North Am. 2005 Nov;17(4):485-501. PubMed PMID: 18088802.

20: Serlo WS, Ylikontiola LP, Vesala AL, Kaarela OI, Iber T, Sándor GK, Ashammakhi N. Effective correction of frontal cranial deformities using biodegradable fixation on the inner surface of the cranial bones during infancy. Childs Nerv Syst. 2007 Dec;23(12):1439-45. Epub 2007 Sep 28. PubMed PMID: 17901962.

21: Ashammakhi N, Renier D, Arnaud E, Marchac D, Ninkovic M, Donaway D, Jones B, Serlo W, Laurikainen K, Törmälä P, Waris T. Successful use of biosorb osteofixation devices in 165 cranial and maxillofacial cases: a multicenter report. J Craniofac Surg. 2004 Jul;15(4):692-701; discussion 702. PubMed PMID: 15213555.

22: Serlo W, Ashammakhi N, Länsman S, Törmälä P, Waris T. A new technique for correction of trigonocephaly using bioabsorbable osteofixation tacks and plates and a novel tack-shooter. J Craniofac Surg. 2003 Jan;14(1):92-6. PubMed PMID: 12544229.

23: Serlo W, Ashammakhi N, Törmälä P, Waris T. A new technique for cranial bone osteofixation: use of bioabsorbable tacks and plates to fix parietal bone split grafts used for reconstruction of a posttraumatic frontal bone defect. J Craniofac Surg. 2002 Mar;13(2):331-6. PubMed PMID: 12000899.

24: Serlo W, Kaarela OI, Peltoniemi HH, Merikanto J, Ashammakhi NA, Lassila K, Pohjonen T, Törmälä P, Waris TH. Use of self-reinforced polylactide osteosynthesis devices in craniofacial surgery: a long-term follow-up study. Scand J Plast Reconstr Surg Hand Surg. 2001 Sep;35(3):285-92. PubMed PMID: 11680397.

25: Ashammakhi N, Peltoniemi H, Waris E, Suuronen R, Serlo W, Kellomäki M, Törmälä P, Waris T. Developments in craniomaxillofacial surgery: use of self-reinforced bioabsorbable osteofixation devices. Plast Reconstr Surg. 2001 Jul;108(1):167-80. Review. PubMed PMID: 11420521.

26: Serlo W, Ashammakhi N, Törmälä P, Waris T. A new technique for correction of trigonocephaly in an infant: application of an absorbable endocranial plate. Childs Nerv Syst. 2000 Sep;16(9):595-7. PubMed PMID: 11048635.

27: Athussaki P, Zepa I, Huggare J, Serlo W, Pirttiniemi P. Frontal head posture in shunt-treated hydrocephalic patients. Childs Nerv Syst. 2000 Jul;16(7):437-40; discussion 441. PubMed PMID: 10958554.

28: Antikainen T, Kallioinen M, Pohjonen T, Törmälä P, Waris T, Serlo W. Polyglycolic acid membrane interpositioning for the prevention of skull deformity following experimental craniosynostosis. Pediatr Neurosurg. 1994;21(1):77-82. PubMed PMID: 7947316.

29: Antikainen T, Pernu H, Törmälä P, Kallioinen M, Waris T, Serlo W. Development of the neurocranium after transsutural fixing by new, resorbable poly-L-lactide miniplates. A comparison to fixing with the common titanium miniplates. Acta Neurochir (Wien). 1994;128(1-4):26-31. PubMed PMID: 7847140.

30: Antikainen T. Silicon membrane interpositioning for the prevention of skull deformity following experimental craniosynostosis. Childs Nerv Syst. 1993 Sep;9(6):321-4. PubMed PMID: 8269412.

31: Antikainen T, Kallioinen M, Waris T, Serlo W. A new method for the creation and measurement of experimental craniosynostosis. Childs Nerv Syst. 1992 Dec;8(8):457-61. PubMed PMID: 1288855.

32: Antikainen T, Ruuskanen M, Taurio R, Kallioinen M, Serlo W, Törmälä P, Waris T. Polylactide and polyglycolic acid-reinforced coralline hydroxy-apatite for the reconstruction of cranial bone defects in the rabbit. Acta Neurochir (Wien). 1992;117(1-2):59-62. PubMed PMID: 1325098.